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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
42.73
Human Site:
Y261
Identified Species:
72.31
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
Y261
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
Y261
V
E
M
A
V
G
R
Y
P
I
P
S
P
D
A
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
Y261
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
Y261
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
Rat
Rattus norvegicus
Q01986
393
43447
Y261
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
Y277
V
E
M
A
I
G
R
Y
P
I
P
P
P
D
S
Chicken
Gallus gallus
Q90891
398
44059
Y263
V
E
L
S
I
G
R
Y
P
I
P
P
P
D
S
Frog
Xenopus laevis
Q05116
395
43724
Y261
V
E
M
A
I
G
R
Y
P
I
P
P
P
D
A
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
R251
K
P
Y
M
A
P
E
R
I
N
P
E
T
N
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
Y280
V
E
M
A
I
G
M
Y
P
I
P
P
P
N
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
Y266
V
E
L
L
I
G
R
Y
P
V
P
A
P
S
Q
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
Y282
V
E
M
A
I
G
R
Y
P
I
P
A
P
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
L258
W
S
L
G
L
V
V
L
E
C
A
T
G
K
F
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
M557
L
G
L
S
I
L
E
M
A
L
G
R
Y
P
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
93.3
100
N.A.
N.A.
100
100
N.A.
86.6
73.3
93.3
6.6
N.A.
73.3
N.A.
53.3
80
P-Site Similarity:
100
93.3
100
N.A.
N.A.
100
100
N.A.
100
100
100
13.3
N.A.
86.6
N.A.
73.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
65
8
0
0
0
8
0
8
15
0
0
43
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
65
0
% D
% Glu:
0
79
0
0
0
0
15
0
8
0
0
8
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
8
0
8
0
79
0
0
0
0
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
50
0
0
0
8
72
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% K
% Leu:
8
0
29
8
8
8
0
8
0
8
0
0
0
0
0
% L
% Met:
0
0
65
8
0
0
8
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
15
0
% N
% Pro:
0
8
0
0
0
8
0
0
79
0
86
58
79
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% Q
% Arg:
0
0
0
0
0
0
72
8
0
0
0
8
0
0
0
% R
% Ser:
0
8
0
15
0
0
0
0
0
0
0
8
0
8
15
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
8
% T
% Val:
79
0
0
0
36
8
8
0
0
8
0
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
79
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _